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Aspartame sugar substitutes cause worrying symptoms from memory loss to brain tumours. But despite US FDA approval as a 'safe' food additive, aspartame is one of the most dangerous substances ever to be foisted upon an unsuspecting public The Most Dangerous Food Additive?Aspartame is the technical name for the brand names Nutrasweet, Equal, Spoonful, and Equal-measure (also Canderel - ed.). Aspartame was discovered by accident in 1965, when James Schlatter, a chemist of G.D. Searle Company, was testing an anti-ulcer drug. Aspartame was approved for dry goods in 1981 and for carbonated beverages in 1983. It was originally approved for dry goods on July 26 1974, but objections filed by neuroscience researcher Dr. John W. Olney and consumer attorney James Turner in August 1974, as well as investigations of G.D. Searle's research practices, caused the US Food and Drug Administration (FDA) to put approval of aspartame on hold (5 December 1974). In 1985, Monsanto purchased G.D.Searle and made Searle Pharmaceuticals and the NutraSweet Company separate subsidiaries.Aspartame is by far the most dangerous substance on the market that is added to foods. Aspartame accounts for over 75% of the adverse reactions to food additives reported to the US FDA. Many of these reactions are very serious, including seizures and death as recently disclosed in a February 1994 Department of Health and Human Services report (1). A few of the 90 different documented symptoms listed in the report as being caused by aspartame include: headaches/migraines, dizziness, seizures, nausea, numbness, muscle spasms, weight gain, rashes, depression, fatigue, irritability, tachycardia, insomnia, vision problems, hearing loss, heart palpitations, breathing difficulties, anxiety attacks, slurred speech, loss of taste, tinnitus, memory loss and joint pain. According to researchers and physicians studying the adverse effects of aspartame, the following chronic illnesses can be triggered or worsened by ingestion of aspartame (2):
Aspartame is made up of three chemicals: aspartic acid, phenylalanine and methanol. The book, Prescriptions for Nutritional Healing, by James and Phyllis Baich, lists aspartame under the category of "chemical poison". As you will see, that is exactly what it is.
How Aspartate (and Glutamate) Cause DamageAspartate and glutamate act as neurotransmitters in the brain by facilitating the transmission of information from neuron to neuron. Too much aspartate or glutamate in the brain kills certain neurons by allowing the influx of too much calcium into the cells. This influx triggers excessive amounts of free radicals which kill the cells. The neural cell damage that can be caused by excessive aspartate and glutamate is why they are referred to as "excitotoxins". They "excite" or stimulate the neural cells to death. Aspartic acid is an amino acid. taken in its free form (unbound to proteins) it significantly raises the blood plasma level of aspartate and glutamate. The excess aspartate and glutamate in the blood plasma shortly after ingesting aspartame or products with free glutamic acid (glutamate precursor) leads to a high level of those neurotransmitters in certain areas of the brain. The blood-brain barrier (BBB), which normally protects the brain from excess glutamate and aspartate as well as toxins,
The excess glutamate and aspartate slowly begin to destroy neurons. The large majority (75%+) of neural cells in a particular area of the brain are killed before any clinical symptoms of a chronic illness are noticed. A few of the many chronic illnesses that have been shown to be contributed to by long-term exposure to amino acid damage include: multiple sclerosis (MS), ALS, memory loss, hormonal problems, hearing loss, epilepsy, Alzheimer's disease, Parkinson's disease, hypoglycaemia, AIDS dementia, brain lesions and neuroendocrine disorders. The risks to infants, children, pregnant women, the elderly and persons with certain chronic health problems from excitotoxins are great. Even the Federation of American Societies For Experimental Biology (FASEB) which usually understates problems and mimics the FDA party-line, recently stated in a review that: "it is prudent to avoid the use of dietary supplements of L-glutamic acid by pregnant women, infants, and children. The existence of evidence of potential endocrine responses, i.e. elevated cortisol and prolactin, and differential responses between males and females, would also suggest a neuroendocrine link and that supplemental L-glutamic acid should be avoided by women of childbearing age and individuals which affective disorders." (4)Aspartic acid from aspartame has the same deleterious effects on the body as glutamic acid. The exact mechanism of acute reactions to excess free glutamate and aspartate is currently being debated. As reported to the FDA, those reactions include (5): headaches/migraines, nausea, abdominal pains, fatigue (blocks sufficient glucose entry into brain), sleep problems, vision problems, anxiety attacks, depression and asthma/chest tightness. One common complaint of persons suffering from the effect of aspartame is memory loss. Ironically, in 1987, G.D. Searle, the manufacturer of aspartame, undertook a search for a drug to combat memory loss caused by excitatory amino acid damage. Blaylock is one of many scientists and physicians who are concerned about excitatory amino acid damage caused by ingestion of aspartame and MSG. One of the many experts who have spoken out against the damage being caused by aspartate and glutamate id Adrienne Samuels, Ph. D., an experimental psychologist specialising in research design. Another is Dr. John Olney, a Professor in the department of Psychiatry, School of Medicine, Washington University, a neuroscientist and researcher, and one of the world's foremost authorities on excitotoxins. (He informed Searle in 1971 that aspartic acid cause holes in the brains of mice.) Also included is Francis J. Waickman, M.D. a recipient of the Rinkel and Forman Awards, and board-certified in paediatrics, allergy and immunology. Other concerned scientists include John R. Hain, M.D., board-certified forensic pathologist, and H.J. Roberts, M.D., FACP., FCCP., diabetes specialist and selected by a national medical publication as "the best doctor in the US". John Samuels is concerned also. He compiled a list of scientific research sufficient to show the dangers of ingesting excess free glutamic and aspartic acid. And there are many more who can be added to this long list.
It has been shown that ingesting aspartame, especially along with carbohydrates, can lead to excess levels of phenylalanine in the brain even in persons who do not have PKU. This is not just a theory, as many people who have eaten large amounts of aspartame over a long period of time and do not have PKU have been shown to have excessive levels of phenylalanine in the blood. Excessive levels of phenylalanine in the brain can cause the levels of serotonin in the brain to decrease, leading to emotional disorders such as depression. it was shown in human testing that phenylalanine levels of the blood were increased significantly in human subjects who chronically used aspartame.(6) Even a single use of aspartame raised the blood phenylalanine levels. In his testimony before the US Congress, Dr. Louis J. Elsas showed that high blood phenylalanine can be concentrated in parts of the brain, and is especially dangerous for infants and foetuses. he also showed that phenylalanine is metabolised much more efficiently by rodents than by humans.(7) One account of a case of extremely high phenylalanine levels caused by aspartame was recently published in the Wednesday Journal in an article entitled "An Aspartame Nightmare". John Cook began drinking six to eight diet drinks every day. His symptoms started out as memory loss and frequent headaches. He began to crave more aspartame-sweetened drinks. His condition deteriorated so much that he experienced wide mood swings and violent rages. Even though he did not suffer from PKU, a blood test revealed a phenylalanine level of 80mg/dl. He also showed abnormal brain function and brain damage. After he kicked the aspartame habit, his symptoms improved dramatically.(8) As Blaylock points out in his book, early studies measuring phenylalanine build-up in the brain were flawed. Investigators who measured specific brain regions and not the average throughout the brain noticed significant rises in phenylalanine levels. Specifically, the hypothalamus, medulla oblongata, and corpus striatum areas of the brain had the largest increases in phenylalanine. Blaylock goes on to point out that excessive build-up of phenylalanine in the brain can cause schizophrenia or make one more susceptible to seizures. Therefore, long-term excessive use of aspartame may provide a boost to sales of serotonin re-uptake inhibitors such as Prozac and drugs to control schizophrenia and seizures.
The absorption of methanol into the body is sped up considerably when free methanol is ingested. Free methanol is created from aspartame when it is heated to above 30C (86F). This would occur when an aspartame-containing product is improperly stored or when it is heated (e.g. as part of a 'food' product such as Jello). Methanol breaks down into formic acid and formaldehyde in the body. Formaldehyde is a deadly neurotoxin. An EPA assessment of methanol states that methanol… "…is considered a cumulative poison due to the low rate of excretion once it is absorbed. In the body, methanol is oxidised to formaldehyde and formic acid: both of these metabolites are toxic." They recommend a limit of consumption of 7.8mg/day. A one-litre (approx. 1 quart) aspartame sweetened beverage contains about 56mg of methanol. Heavy users of aspartame-containing products consume as much as 250mg of methanol daily or 32 times the EPA limit.(9) Symptoms from methanol poisoning include: headaches, ear buzzing, dizziness, nausea, gastrointestinal disturbances, weakness, vertigo, chills, memory lapses, numbness and shooting pains in the extremities, behavioural disturbances, and neuritis. The most well-known problems from methanol poisoning are vision problems, including misty vision, progressive contraction of visual fields, blurring of vision, obscuration of vision, retinal damage and blindness. formaldehyde is a known carcinogen, causes retinal damage, interferes with DNA replication and causes birth defects.(10) Due to the lack of a couple of key enzymes, humans are many times more sensitive to the toxic effects of methanol than animals. Therefore, tests of aspartame or methanol on animals do not accurately reflect the danger for humans. As pointed out by Dr. Woodrow C. Monte, Director of the Food Science and Nutrition Laboratory at Arizona State University, "There are NO human or mammalian studies to evaluate the possible mutagenic, teratogenic or carcinogenic effects of chronic administration of methyl alcohol." (11) He was so concerned about the unresolved safety issues that he filed suit with the FDA, requesting a hearing to address these issues. He asked the FDA to… "…slow down on this soft-drink issue long enough to answer some of the important questions. It's not fair that you are leaving the full burden of proof on the few of us who are concerned and have such limited resources. You must remember that you are the American public's last defence. Once you allow usage {of aspartame}, there is literally nothing I or my colleagues can do to reverse the course. Aspartame will then join saccharin, the sulfiting agents and God knows how many other questionable compounds enjoined to insult the human constitution with governmental approval."(10) Shortly thereafter, the Commissioner of the FDA, Arthur Hull Hayes, Jr., approved the use of aspartame in carbonated beverages. He then left for a position with G.D .Searle's public relations firm. (11) It has been pointed out that some fruit juices and alcoholic beverages contain small amounts of methanol. It is important to remember, however, that methanol never appears alone. In every case, ethanol is present, usually in much higher amounts. Ethanol is an antidote for methanol toxicity in humans.(9) The troops of Desert Storm were "treated" to large amounts of aspartame-sweetened beverages which had been heated to over 86F in the Saudi Arabian sun. Many of them returned home with numerous disorders similar to what has been seen in persons who have been chemically poisoned by formaldehyde. The free methanol in the beverages may have been a contributing factor in these illnesses. Other breakdown products of aspartame such as DKP (discussed below) may also have been a factor. In a 1993 act that can only be described as unconscionable, the FDA approved aspartame as an ingredient in numerous food items that would always be heated to above 30C (86F).
Breakdown of aspartame and L-phenylalanine methyl ester, DKP, L-aspartylphenlalanine, and L phenylalanine, at bottling time, after six months, and after 36 months*
(* From: Tsang, Wing-Sum, et al. (1985), "Determination of Aspartame and its Breakdown Products in Soft Drinks by Reverse-Phase Chromatography with UV Detection" Journal of Agriculture and Food Chemistry, vol.33, no.4, pp. 734-738.) G.D.Searle conducted animal experiments on the safety of DKP. The FDA found numerous experimental errors occurred, including "clerical errors, mixed-up animals, animals not getting drugs they were supposed to get, pathological specimens lost because of improper handling" and many other errors. (12) These sloppy laboratory procedures may explain why both the test and control animals had 16 times more brain tumours than would be expected in experiments of this length. In an ironic twist, shortly after these experimental errors were discovered, the FDA used guidelines recommended by G.D.Searle to develop the industry-wide FDA standards of Good Laboratory Practices. (11) DKP has also been implicated as a cause of uterine polyps and changes in blood cholesterol by FDA toxicologist Dr. Jacqueline Verrett in her testimony before the US Senate.
(13)
There is an enormous population of people who are suffering from symptoms contributed to by aspartame, yet they have no idea why herbs or drugs are not helping relieve their problems. There are other users of aspartame who appear not to be suffering immediate reactions to aspartame. But even these individuals are susceptible to the long-term damage caused by excitatory amino acids, phenylalanine, methanol and DKP. A few of the many disorders that are of particular concern to me include the following:
Why Don't We Hear About These ThingsThe reasons many people do not hear about serious reactions to aspartame are twofold:
Eric Millstone, a researcher at the Science Policy Research Unit of Sussex University, UK has compiled thousands of pages of evidence, some of which has been obtained using the Freedom of Information Act (25), showing:
A Public Board of Inquiry (PBoI) was conducted in 1980. There were three scientists who reviewed the objections of Olney and Turner to the approval of aspartame. They voted unanimously against aspartame's approval. The FDA Commissioner, Dr. Arthur Hull Hayes Jr., then created a five-person Scientific Commission to review the PBoI findings. After it became clear that the Commission would uphold the PBoI's decision by a vote of 3 to 2, another person was added to the Commission, creating a dead-locked vote. This allowed the FDA Commissioner to break the deadlock and approve aspartame for dry goods in 1981. Dr. Jacqueline Verrett, the Senior Scientist in an FDA Bureau of Foods review team created in August 1977 to review the Bressler Report (a report that detailed G.D.Searle's abuses during the pre-approval testing), said: It was pretty obvious that, somewhere along the line, the bureau officials were working up to a whitewash. In 1987, Verrett testified before the US Senate, stating that the experiments conducted by Searle were a 'disaster'. She said that her team was instructed not to comment on or be concerned with the overall validity of the studies. She stated that questions about birth defects have not been answered. She continued her testimony by discussing the fact that DKP has been shown to increase uterine polyps and change blood cholesterol, and that increasing the temperature of the product leads to an increase in production of DKP.(26)
It is important to realise that this type of revolving-door activity has been going on for decades. The Townsend Letter for Doctors (11/92) reported on a study revealing that 37 of 49 top FDA officials who left the FDA took positions with companies that had regulated. They also reported that over 150 FDA officials owned stock in drug companies they were assigned to manage. Many organisations and universities receive large sums of money from companies connected to The NutraSweet Association, a group of companies promoting the use of aspartame. In January 1993, the American Dietetic Association received a US$75,000 grant from The NutraSweet Company. The American Dietetic Association has stated that The NutraSweet company writes their 'facts' sheets. (28) Many other 'independent' organisations and researchers receive large sums of money from the manufacturers of aspartame. The American Diabetes Association received a large amount of money from NutraSweet, including money to run a cooking school in Chicago (presumably to teach diabetics how to use NutraSweet in their cooking). A researcher in New England who pointed out the dangers of aspartame in the past is now a Monsanto consultant. Another researcher in the south-eastern US testified about the dangers of aspartame on foetuses. An investigative reporter was told to keep his mouth shut to avoid causing the loss of a large grant from a diet cola manufacturer in the NutraSweet Association. What is the FDA doing to protect the consumer from the dangers of aspartame? Less than nothing. In 1992, the FDA approved aspartame for its use in malt beverages, breakfast cereals and refrigerated puddings and fillings. in 1993, the FDA approved aspartame for use in hard and soft candies, non-alcoholic flavoured beverages, tea beverages, fruit juices and concentrates, baked goods and baking mixes, and frostings, toppings and fillings for baked goods. In 1991, the FDA banned the importation of stevia. The powder of the leaf has been used for hundreds of years as an alternative sweetener. It is used widely in Japan with no adverse effects. Scientists involved in reviewing stevia have declared it to be safe for human consumption - something which has been well-known in many parts of the world where it is not banned. Everyone that I have spoken with in regard to this issue believes that stevia was banned to keep the product from taking hold in the US and cutting into sales of aspartame. (29) What is the US Congress doing to protect the consumer from the dangers of aspartame? Nothing. What is the US Administration (President) doing to protect the consumer from the dangers of aspartame? Nothing. Aspartame consumption is not only a problem in the USA. It is being sold in over 70 countries throughout the world. I have been told that aspartame has been found in products where it is not listed on the label. One must be particularly careful of pharmaceuticals and supplements. I have been informed that even some supplements made by well-known supplement manufacturers such as Twinlabs contain aspartame. The information I have related above is just the tip of the ice-berg in terms of damaging information about aspartame. In order for the reader to find out more, I have included some resources below.
Footnotes
1. Department of Health and Human Services, "Report on All Adverse Reactions in the Adverse Reactions Monitoring System", 25 and 28 February 1994.
2. Compiled by researchers, physicians, and artificial sweetener experts for Mission Possible, a group dedicated to warning consumers about aspartame. 3. Blaylock, Russell MD, Excitotoxins: The Taste That Kills. 4. Life Sciences Research Office, Safety of Amino Acids , FASEB, FDA Contract no. 223-88-2124, Task Order No.8 5. FDA Adverse Reaction Monitoring System. 6. Wurtman and Walker, "Dietary Phenylalanine and Brain Function", Proceedings of the First International Meeting on Dietary Phenylalanine and Brain Function, Washington DC USA, 8 May 1987. 7. Hearing Before the Committee on Labor and Human Resources, First Session on Examining the Health and Safety Concerns of NutraSweet (aspartame), United States Senate. 8. Account of John Cook as published in: Mullarkey, Barbara, "How Safe Is Your Artificial Sweetener?", Informed Consent, magazine, September/October 1994. 9. Monte, Woodrow C., Ph.d, RD "Aspartame: Methanol and the Public Health", Journal of Applied Nutrition, 36(1):42-53. 10. US Court of Appeals for the District of Columbia Circuit, No.84-1153, Community Nutrition Institute and Dr Woodrow Monte v. Dr Mark Novitch, Acting Commissioner, US FDA, 24 September 1985. 11. Mullarkey, Barbara, "Aspartame Time Line", Informed Consent, May/June 1994. 12. FDA Searle Investigation Task Force, "Final Report of Investigation of G.D. Searle Company", 24 March 1976. 13. Testimony of Dr Jacqueline Verrett, FDA toxicologist before the US Senate Committee on Labor and Human Resources, 3 November 1987. 14. Internal FDA memorandum. 15.Analysis prepared by Dr John Olney as a statement before the Aspartame Board of Inquiry of the FDA. Also, Blaylock, Russell MD, Excitotoxins: The Taste That Kills. 16. Congressional Record SID835:131, 1 August 1985. 17. FDA Searle Investigation Task Force, "Final Report of Investigation of G.D.Searle Company", 24 March 1976. 18. National Cancer Institute SEER Program Data. 19. FDA Adverse Reaction Monitoring System. 20. Walton, Ralph G., Robert Hudak, Ruth Green-Waite, "Adverse Reactions to Aspartame: Double-Blind Challenge in Patients from a Vulnerable Population", Biological Psychiatry (1993), 34:13-17. 21. Mullarkey, Barbara, "How Safe Is Your Artificial Sweetener?", Informed Consent Magazine, September/October 1994. 22. US Air Force, "Aspartame Alert", Flying Safety, 48(5):20-21, May 1992. 23. Reported by the Aspartame Consumer Safety Network. 24. Mullarkey, Barbara (ed.), Bittersweet Aspartame: A Diet Delusion. 25. Millstone, Eric, "Sweet and Sour", The Ecologist, no.25, March/April 1994. 26. Testimony of Dr Jacqueline Verrett, FDA Toxicologist, before the US Senate Committee on Labor and Human Resources, 3 November 1987. 27. Stoddard, Mary Nash (ed.), The Deadly Deception, Aspartame Consumer Safety Network. 28. ADA Courier vol.32, no.1, January 1993. 29. Blumenthal, Mark, "FDA Rejects AHPA Stevia Petition", Whole Foods, April 1994. References* Note. Most titles available from the Aspartame Consumer Safety Network. * Blaylock, Russell L., Excitotoxins: The Taste That Kills, Health Press, Santa Fe, New Mexico, USA 1994.
THE ASPARTAME CONSUMER SAFETY NETWORK
PO Box 780634, Dallas, Texas 75378, USA. Phone: +1 (214)352 4268
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